Table 1.
Patient group characteristics.
| Radiographic progressors (cases) (n = 58), mean ± SEM | Nonprogressors (controls) (n = 58), mean ± SEM | 2-tailed P value | |
|---|---|---|---|
| Baseline characteristics | |||
| Age | 60 ± 1 | 60 ± 1 | 0.90 |
| Sex (% female) | 53.4% | 60.3% | 0.13 |
| BMI | 30.5 ± 0.5 | 30.9 ± 0.6 | 0.61 |
| Ethnicity (% caucasian) | 88% | 88% | 1.00 |
| Smoking (% positive) | 46% | 43% | 0.71 |
| NSAID use (% positive) | 29% | 17% | 0.13 |
| Mean WOMAC pain (0–100 point normalized scale) | 21.5 ± 2 | 17.0 ± 1.5 | 0.05 |
| Mean JSW (mm) | 3.9 ± 0.1 | 4.0 ± 0.1 | 0.34 |
| Baseline K/L grade 2 | 25 | 35 | 0.09 |
| Baseline K/L grade 3 | 33 | 23 | |
| Baseline estimated PBMC composition | |||
| CD8 + T cells | 8.5 ± 0.7% | 8.6 ± 0.6% | 0.9 |
| CD4 + T cells | 21 ± 0.9% | 21 ± 1% | 0.9 |
| NK cells | 7.4 ± 0.5% | 7.6 ± 0.6% | 0.9 |
| B cells | 9.6 ± 0.5% | 9.8 ± 0.5% | 0.8 |
| Monocytes | 7.4 ± 0.3% | 6.7 ± 0.3% | 0.12 |
| Granulocytes | 51 ± 1% | 51 ± 1% | 0.9 |
| Baseline comorbidities | |||
| Type 2 diabetes | 4 (patients/58) | 6 (# patients/58) | 0.74 |
| History of heart attack | 0 | 0 | n/a |
| History of heart failure | 2 | 3 | 1.0 |
| History of stroke | 2 | 4 | 0.68 |
| History of lung disease | 0 | 0 | n/a |
| History of cancer | 1 | 4 | 0.36 |