Table 2.

Performance of PBMC DNA methylation models to predict future radiographic progression in OA patients when evaluating previously unseen data.

	M-value based models (mean ± SEM)	Beta value-based models (mean ± SEM)
ROC-AUC (c-statistic)	0.81 ± 0.01	0.75 ± 0.01
Accuracy	73 ± 1%	69 ± 1%
Odds ratio	11 ± 2	9 ± 2
Sensitivity	74 ± 1%	73 ± 2%
Specificity	70 ± 1%	70 ± 1%