Table 3.
Top 20 CpGs selected for supervised model development. CpGs shared by both Beta-value-based and M-value-based models are highlighted in bold (n = 7).
| M value-based algorithm feature | # of development rounds selected (out of 40) | Associated gene | CpG location (regulatory region) | Location within CpG island | Beta value-based algorithm feature | # of development rounds selected (out of 40) | Associated gene | CpG location (regulatory region) | Location within CpG island |
|---|---|---|---|---|---|---|---|---|---|
| cg15974085 | 15 | C18orf55; FBXO15 | TSS200 | Island | cg11865413 | 15 | N_Shelf | ||
| cg26384229 | 14 | ALG10B | TSS200 | Island | cg21643086 | 15 | |||
| cg21643086 | 12 | cg17745251 | 11 | C10orf140 | Body | Island | |||
| cg03687650 | 11 | OSBPL5 | Body | S_Shelf | cg06409741 | 11 | RASA3 | Body | Island |
| cg06409741 | 11 | RASA3 | Body | Island | cg03870777 | 10 | KRT18 | TSS200 | N_Shore |
| cg18111500 | 10 | cg17956079 | 10 | PLEKHB1 | TSS200 | ||||
| cg07772660 | 9 | MST1P9 | Body | Island | cg26384229 | 9 | ALG10B | TSS200 | Island |
| cg11865413 | 9 | N_Shelf | cg03687650 | 7 | OSBPL5 | Body | S_Shelf | ||
| cg03212634 | 9 | cg10306485 | 7 | RASA3 | Body | S_Shelf | |||
| cg00142933 | 8 | LIMS2 | Body | N_Shore | cg19559392 | 7 | MORN2; DHX57 | 5′UTR; TSS1500 | S_Shore |
| cg16001460 | 8 | PRIM2 | TSS1500 | cg05587853 | 7 | MSL2 | TSS1500 | Island | |
| cg17745251 | 7 | C10orf140 | Body | Island | cg14616423 | 7 | |||
| cg14330460 | 7 | cg08728848 | 6 | ||||||
| cg03870777 | 6 | KRT18 | TSS200 | N_Shore | cg07379140 | 5 | ALG14 | TSS200 | Island |
| cg02215141 | 6 | N_Shore | cg02962630 | 5 | DLL4 | Body | Island | ||
| cg20200361 | 6 | THADA | Body | cg16790849 | 5 | NEU1 | Body | N_Shore | |
| cg07258847 | 6 | cg00143249 | 5 | MNX1 | Body | Island | |||
| cg23226134 | 5 | CLCN6;MTHFR | 1st Exon | Island | cg10609068 | 4 | ANO6 PLEKHA9 | TSS1500; 5′UTR | N_Shore |
| cg16121685 | 5 | UHMK1 | TSS200 | Island | cg14710040 | 4 | EEF2 | TSS200 | Island |
| cg10966582 | 5 | MST1P9 | Body | Island | cg17310773 | 4 | SLC25A17 | 1stExon | Island |