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. 2019 Nov 14;10:5155. doi: 10.1038/s41467-019-13033-4

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© The Author(s) 2019, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Clcn2^R180Q/+ mice have higher blood pressure. Blood pressure (BP) and heart rate (HR) of animals assessed through telemetry sensors. Shown are loess regressions of BP/HR of WT (black, N = 18 biologically independent animals) and Clcn2^R180Q/+ (red, N = 18 biologically independent animals) animals, with gray intervals denoting 95% confidence intervals for loess regressions. Horizontal axis shows time, with black markers noting nights (active periods of nocturnal animals). Horizontal lines show mean for the entire measurement period for WT (black dash-dotted) and Clcn2^R180Q/+ (red dashed) animals. Nested-model likelihood ratio comparisons reveal significantly higher BP (systolic, P = 0.007; diastolic P = 0.020, MAP, P = 0.009) of Clcn2^R180Q/+ animals than WT and unchanged HR (p=0.225). Average (mean ± SEM for all) systolic BP is 116.4 ± 0.1 mmHg (WT) and 120.6 ± 0.1 mmHg (Clcn2^R180Q/+). Average diastolic BP is 84.2 ± 0.1 mmHg (WT) and 88.0 ± 0.1 mmHg (Clcn2^R180Q/+). Average MAP is 100.1 ± 0.1 mmHg (WT) and 103.8 ± 0.1 mmHg (Clcn2^R180Q/+). Average HR is 495.2 ± 0.4 BPM (WT) and 507.9 ± 0.4 BPM (Clcn2^R180Q/+)