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. 2019 Nov 14;9:16810. doi: 10.1038/s41598-019-53346-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ATH and MCD diets induce similar degree of steatosis, but different NASH severity. Liver weight expressed in grams (A) and as percentage of body weight. (B) Plasma levels of liver enzymes: ALT (C) and AST. (D) Liver histology: hematoxylin and eosin (H&E), Oil Red O, Sirius Red and periodic acid Schiff (PAS). (E) SAF score with Steatosis, Activity (lobular inflammation + ballooning) and Fibrosis. (F) Evaluation of the percent of hepatocyte containing micro- and macrosteatosis. (G) Quantification of lipids (H), collagen (I) and glycogen (J) expressed as percent of area stained respectively with Oil red O, Sirius Red and PAS. Scale bars 100 µm, black arrows: immune cell infiltration, white arrows: macrosteatosis, grey arrow: microsteatosis, yellow dashed circle: lipogranuloma. One-way ANOVA: *p value ATH/MCD vs CTRL < 0.05, ^#p value MCD vs ATH < 0.05.