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. 2019 Nov 14;9:16810. doi: 10.1038/s41598-019-53346-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Liver lipidomics highlights effects of ATH and MCD diets on phospholipid homeostasis including phospholipid composition, fatty acid chain length and level of desaturation. Relative concentration of lipid classes. (A) Phosphatidylcholine to phosphatidylethanolamine ratio. (B) Total amount of PC, PE, PI and PS represented according to the nature of the fatty acid linkage (diacyl vs alkyl-acyl (ether) or monoacyl (lyso) (C), degree of saturation (D) or chain length (E). Same as in ‘C-E’ but separately for phosphatidylcholine (F), phosphatidylethanolamine (G), phosphatidylinositol (H) or phosphatidylserine. (I) PC: phosphatidylcholine, PE: phosphatidylethanolamine, PI: phosphatidylinositol, PS: phosphatidylserin1e, SL: sphingolipids, CL: cardiolipin, diacyl: diacylphospholipids, ether: alkyl-acyl-containing phospholipids, lyso: lysophospholipids, SFA: saturated fatty acids, MUFA: monounsaturated fatty acids (total sum of 1 double bond in both fatty acyl chains), PUFA: polyunsaturated fatty acids (total sum of 2–6 double bonds in both fatty acyl chains), LC: long chains (total sum of 28–34 carbons in both fatty acyl chains), VLC: very long chains (total sum of 36–44 carbons in both fatty acyl chains). One-way ANOVA: ^*p value ATH/MCD vs CTRL < 0.05, ^#p value MCD vs ATH < 0.05.