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. 2019 Nov 14;10(11):867. doi: 10.1038/s41419-019-2098-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Representative immunoblots of cyclin E, phosphor-CDK2, total CDK2, and actin for tumor cell lysates obtained from untreated cisplatin naϊve (gray) and cisplatin-resistant xenografts (black). b Quantification by photo densitometry was performed on bands using Image Lab Software, cyclin E levels were normalized to β-actin loading control, and the ratio of p-CDK2/total CDK2 was calculated. c Representative immunoblots of cisplatin-resistant tumor cell lysates after 14 days of daily treatment with either vehicle control (black) or palbociclib (blue). Lysates were harvested 24 h after final dosing. d Accompanying quantification by photo densitometry. All quantification is presented as mean ± SD. (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001, by Student’s t-test)