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. 2019 Nov 8;10:1103. doi: 10.3389/fgene.2019.01103

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Copyright © 2019 Sasai, Toriyama and Kondo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The processing of Hh proteins and their intracellular signaling pathways. (A) Cleavage of Hh polypeptides and their modifications in ER and golgi apparatus. (B) Processing, modifications and transport of Hh proteins in the producing cells. (C) Active signaling pathways in absence and in presence of Hh molecules. Schemas in dotted rectangles represent regulation of cAMP level in the cilia. The figure was made based on the information in (Varjosalo and Taipale, 2008; Balaskas et al., 2012; Moore et al., 2016; Parchure et al., 2018).