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. 2019 Nov 8;7:289. doi: 10.3389/fbioe.2019.00289

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Copyright © 2019 Thakur, Medintz and Walper.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enhancement of PTE activity through scaffolded DNA assemblies. Pyramidal DNA cages were assembled using three-way DNA junctions that presented terminal hexahistidine sequences allowing for the positional assembly of QDs and recombinant PTE (A). The initial velocity of each construct was tested in parallel (B) with “8 PTE” correlating to 8 free enzymes, “QD-PTE” correlating to 8 enzymes on each 540 nm QD, and “8 cage/QD-PTE” defining the assembled structure of (A). Reproduced with permission (Samanta et al., 2018), Copyright the American Chemical Society 2018.