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. 2019 Nov 14;9:16786. doi: 10.1038/s41598-019-52903-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Infertility patients’ semen and sperm parameters upon recruitment (Pre-Conc 0) prior to FSH therapeutic treatment (Pre-Conc 1) and after 3 months of treatment (Post-Conc 2) for individual patients listed (color designated). Sample analyses for all patients are presented in (a) Semen concentration, (b) Percent motility sperm, and (c) Total motility count (TMC) (semen volume x concentration x motility). Infertility patients responding with >2-fold change following treatment are presented, (d) Semen concentration, (e) Percent motility sperm, and (f) TMC. The y-axis is magnitude of change between collections.