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. 2019 Nov 14;9:16786. doi: 10.1038/s41598-019-52903-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DMR identifications. (a) Fertility vs Infertility Sperm DMR Analysis. The number of DMRs found using different p-value cutoff thresholds. The all window column shows all DMRs. The multiple window column shows the number of DMRs containing at least two adjacent significant windows and the number of DMRs with each specific number of significant windows at a p-value threshold of 1e-05. (b) Infertility patient responder vs non-responder sperm DMRs. The number of DMRs found using different p-value cutoff thresholds. The all window column shows all DMRs. The multiple window column shows the number of DMRs containing at least two significant windows. The number of DMRs with each specific number of significant windows at a p-value threshold of 1e-05. (c) Venn diagram DMR signature for fertile vs infertile p < 1e-05 and DMR signature responder vs. non-responder at p < 1e-05 and p < 0.001. (d) DMR associated gene categories.