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. 2019 Nov 14;9:16786. doi: 10.1038/s41598-019-52903-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Principal component analysis. (a) Fertility vs Infertility DMR Principal Component Analysis for Individuals. The samples are plotted by the first three principal components. The underlying data is the RPKM read depth for the DMRs. The color code is listed for the fertile and infertile patients. (b) Fertility vs Infertility DMR Principal Component Analysis for Individuals. The samples are plotted by the first three principal components. The underlying data is the RPKM read depth for the DMRs. The color code is listed for the fertile and infertile patients. Selection failure correlations for fertile and infertile patients not used to generate the epigenetic signature. PCA Infertile vs Fertile p < 10⁻⁵. (c) Responder and non-responder PCA analysis for DMRs at p < 1e-05. The first three principal components used and samples color code index indicated. The underlying data is the RPKM read depth for all DMRs. (d) The number of DMR for fertility versus infertility comparison for all permutation analyses. The vertical red line shows the number of DMR found in the original analysis. All DMRs are defined using an edgeR p-value threshold of p < 1e-05.