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. Author manuscript; available in PMC: 2019 Nov 15.
Published in final edited form as: J Med Chem. 2019 Oct 31;62(21):9718–9731. doi: 10.1021/acs.jmedchem.9b01155

Table 2.

BBB penetration of 17 (PO, 20 mg/kg) in mice (n=3, mean ± SD) at various time points

0.5 h 1 h 4 h
Brain (ng/g) 21.25 ± 16.90 20.48 ± 4.19 6.58 ± 11.39
Plasma (ng/mL) 277.33 ± 182.15 57.60 ± 55.65 8.00 ± 10.51
Brain-to-Plasma ratio 0.077 0.36 0.82