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Volcano plot displaying differential plasma miRNA expression in the discovery cohort (n=167 RA vs n=91 control subjects). Small RNA sequencing was analyses by DESeq2 and adjusted for age, race, sex and batch and multiple comparisons. Among these 110 were ≥1.5 fold altered in RA compared to control subjects. Each dot represents an individual miRNA and the larger the dot the more abundant the miRNA is. Red indicates increased in RA and blue indicates increased in control subjects.
