Table 3a.

Association of childhood physical and emotional abuse as measured by the CTQ with risk of incident SLE in the NHS II cohort (N=67,516)

CTQ Response	SLE Cases/person-years	Model A HR (95% CI)	Model B HR (95% CI)	Model C HR (95% CI)
None/Very low	11/361,724	Ref.	Ref.	Ref.
Low	24/407,066	1.92 (0.94–3.92)	1.89 (0.92–3.87)	1.85 (0.90–3.79)
Moderate	25/493,200	1.66 (0.81–3.38)	1.58 (0.78–3.23)	1.52 (0.74–3.09)
High	34/386,815	2.81 (1.42–5.56)	2.57 (1.30–5.12)	2.38 (1.19–4.74)
p for trend		p=0.004	p=0.01	p=0.03

Model A: Age and race-adjusted

Model B: Age, race and parental and childhood factor (maternal and paternal occupation, parental education, parental home ownership, birthweight, age at menarche, somatogram score at age 5) adjusted

Model C: Age, race, parental and childhood factor, and adult BMI and smoking adjusted