FIGURE 1.

a) Proto-oncogene tyrosine-protein kinase receptor Ret (RET) in controls and disease groups. AU: arbitrary units; PAH: pulmonary arterial hypertension; CTEPH: chronic thromboembolic pulmonary hypertension; PH-HFpEF: pulmonary hypertension due to diastolic heart failure (preserved ejection fraction); PH-HFrEF: pulmonary hypertension due to systolic heart failure (reduced ejection fraction); non-PH-HF: heart failure without pulmonary hypertension. RET was reduced in plasma in PAH compared with the other disease groups and controls. *: p<0.05; **: p<0.01; ****: p<0.0001. b) Receiver operating characteristics of RET as a predictor of PAH among other pulmonary hypertension groups.