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. 2019 Nov 8;7:296. doi: 10.3389/fbioe.2019.00296

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Copyright © 2019 Battisti, Vecchione, Casale, Pennacchio, Lettera, Jamaledin, Profeta, Di Natale, Imparato, Urciuolo and Netti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphical Abstract — Highly controlled intradermal delivery can be performed with multi-compartmental polymer microneedles that are able to indent the skin and be implanted in it with a fast dissolving tip and a slow degradable body made of porous PLGA μPs.