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. 2019 Nov 8;7:296. doi: 10.3389/fbioe.2019.00296

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Copyright © 2019 Battisti, Vecchione, Casale, Pennacchio, Lettera, Jamaledin, Profeta, Di Natale, Imparato, Urciuolo and Netti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Optical image of microneedles molded at various steps. (A) Master of 600 um of height and 300 um of bases of microneedles fabricated by 2PP, (B) PDMS stamp replicated on the master, and (C) cross-section of the PDMS mold. (D) NOA master replicated on the PDMS stamp, and (E) final PDMS stamp replicated on it (F) including a cross-section. A comparison of photos (C,F) reveal how, despite the various stages of replication, the needles keep tips with the same curvature radius.