Table 3.
Univariate analysis to identify variables associated with overall survival
| Variables | HR | 95% CI | P |
|---|---|---|---|
| Age, ≥60 versus <60 (years) | 1.25 | 1.16-2.4 | 0.37 |
| Sex, male versus female | 2.54 | 1.12-3.77 | 0.23 |
| Family history, positive versus negative | 2.31 | 0.71-4.91 | 0.45 |
| Tumor size (cm) | |||
| <1 | Reference | ||
| 1-3 | 1.72 | 1.25-10.54 | 0.45 |
| >3 | 3.24 | 1.9-5.31 | 0.021 |
| Metastasis | |||
| Absence | Reference | ||
| Presence | 4.31 | 2.14-6.42 | 0.001 |
| A known | 1.7 | 0.68-3.87 | 0.24 |
| Involved lymph nodes >2 versus ≤2 | 3.89 | 1.67-5.63 | 0.001 |
| Cirrhosis, positive versus negative | 1.94 | 0.77-4.150 | 0.24 |
| Child-Pugh class | |||
| None | Reference | ||
| A | 2.31 | 0.91-4.87 | 0.27 |
| B | 1.61 | 1.01-2.67 | 0.38 |
| C | 1.04 | 0.8-2.5 | 0.57 |
| Liver lobe of involved | |||
| Right | Reference | ||
| Left | 2.45 | 0.5-3.15 | 0.44 |
| Both | 3.6 | 0.9-4.6 | 0.3 |
| Serum AFP level (ng/mL) | |||
| <10 | Reference | ||
| 10-400 | 0.88 | 0.52-3.54 | 0.26 |
| >400 | 0.97 | 0.61-2.11 | 0.61 |
| Treatment type | |||
| Surgery | Reference | ||
| Chemotherapy | 0.91 | 0.51-3.29 | 0.28 |
| Surgery + chemotherapy | 0.38 | 0.11-0.82 | 0.001 |
| Other | 2.37 | 1.5-4.2 | 0.046 |
| Hepatitis type | |||
| None | Reference | ||
| HBV | 2.1 | 1.24- 3.58 | 0.088 |
| HCV | 2.6 | 1.51-4.3 | 0.095 |
| HBV + HCV | 3.4 | 1.77-5.19 | 0.001 |
HR=Hazards ratio, CI=Confidence interval; HBV=Hepatitis B virus; HCV=Hepatitis C virus; AFP=Alpha-fetoprotein