Table 1.
Clinicopathological characteristics of patients with PDAC: univariate and multivariate analysis.
| Variables | Patients (n=97) |
OS | RFS | ||||
|---|---|---|---|---|---|---|---|
| Univariate P-value |
Multivariate P-value |
Multivariate HR (95% CI) | Univariate P-value |
Multivariate P-value |
Multivariate HR (95% CI) |
||
| Gender, male/female | 52/45 | 0.676 | NA | 0.430 | NA | ||
| Age, years(medium,range) | 64, 35-81 | 0.309 | NA | 0.317 | NA | ||
| Differentiation, well and moderate/poor | 29/68 | 0.221 | NA | 0.608 | NA | ||
| Vascular invasion, yes/no | 15/82 | 0.766 | NA | 0.710 | NA | ||
| Tumor size, ≤ 4/ > 4 cm | 42/55 | 0.515 | NA | 0.133 | NA | ||
| TNM stage, I+IIA/IIB+III | 55/42 | 0.003 | 0.001 | 2.177(1.380-3.435) | 0.001 | 0.001 | 2.191(1.396-3.439) |
| preCA19-9, < 37/ ≥ 37 U/L | 23/74 | 0.208 | NA | 0.307 | NA | ||
| preCEA, < 5/ ≥ 5 ng/mL | 76/21 | 0.271 | NA | 0.602 | NA | ||
| preNeutrophil, ≤ 6.3/ >6.3 *109/L | 90/7 | 0.084 | NA | 0.049 | 0.346 | 1.506(0.643-3.532) | |
| preLymphocyte, < 1.1/ ≥ 1.1 *109/L | 9/88 | 0.825 | NA | 0.959 | NA | ||
| preMonocyte, ≤ 0.6/ >0.6 *109/L | 87/10 | 0.019 | 0.027 | 2.214(1.093-4.486) | 0.051 | NA | |
| preALB, <35/ ≥ 35 g/L | 3/94 | 0.811 | NA | 0.983 | NA | ||
| preALT, ≤ 50/ > 50 U/L | 95/2 | 0.505 | NA | 0.836 | NA | ||
| preGGT, ≤ 60/ > 60 U/L | 86/11 | 0.889 | NA | 0.606 | NA | ||
| preLDH, ≤245/ >245 U/L | 93/4 | 0.440 | NA | 0.375 | NA | ||
| poNeutrophil, ≤ 11.65/ >11.65 *109/L | 28/69 | 0.075 | NA | 0.029 | 0.295 | 1.366(0.762-2.447) | |
| poLymphocyte, < 1.1/ ≥ 1.1 *109/L | 51/46 | 0.449 | NA | 0.403 | NA | ||
| poALB, <35/ ≥ 35 g/L | 45/52 | 0.195 | NA | 0.609 | NA | ||
| poALT, ≤ 50/ > 50 U/L | 87/10 | 0.905 | NA | 0.882 | NA | ||
| poGGT, ≤ 60/ > 60 U/L | 87/10 | 0.703 | NA | 0.830 | NA | ||
| poLDH, ≤245/ >245 U/L | 50/47 | 0.886 | NA | 0.558 | NA | ||
| preLMR, ≤ 5.8/ >5.8 | 65/32 | 0.013 | 0.078 | 0.630(0.377-1.053) | 0.036 | 0.150 | 0.704(0.436-1.135) |
| preAGR, ≤ 1.66/ >1.66 | 41/56 | 0.978 | NA | 0.432 | NA | ||
| preALR, ≤ 0.227/ >0.227 | 39/58 | 0.375 | NA | 0.232 | NA | ||
| poNLR, ≤ 14.1/ >14.1 | 51/46 | 0.012 | 0.044 | 1.618(1.014-2.582) | 0.003 | 0.028 | 3.378(1.141-9.999) |
| poAGR, ≤0.92/ > 0.92 | 22/75 | 0.682 | NA | 0.566 | NA | ||
| poALR, ≤ 0.151/ >0.151 | 54/43 | 0.035 | 0.108 | 0.683(0.428-1.087) | 0.042 | 0.152 | 0.714(0.450-1.132) |
| △NLR, ≤ 12.1/ >12.1 | 53/44 | 0.053 | NA | 0.026 | 0.137 | 0.431(0.142-1.309) | |
OS, overall survival; RFS, relapse free survival; NLR, neutrophil-to-lymphocyte ratio; NA, not available. P values <0.05 are highlighted in bold font.