Figure 6.

Schematic diagram of proposed mechanisms of DHA-induced autophagy. DHA suppresses Akt activity and its downstream mTOR signaling pathway. MTOR inhibits the formation of phagophore, which initiates autophagy by expanding to an autophagosome. During the expansion from phagophore to autophagosome, cytoplasmic LC3-I is conjugated with phosphatidyl ethanolamine (PE) and is changed into LC3-II. LC3-II is recruited to the membrane of phagophore and autophagosome, and then autophagy is induced.