Table 3.
Multivariate Cox regression analyses for AML patients with chemotherapy by causes of death. Data are hazard ratios, with 95% confidence interval in parentheses.
| Strata | N | Cause-specific hazards ratios | |||
|---|---|---|---|---|---|
| Cardiac | P-value | AML | P-value | ||
| Age | |||||
| 0-14 | 3004 | Reference | Reference | ||
| 15-29 | 4037 | 1.34 (0.69-2.60) | 0.388 | 1.22 (1.13-1.32) | < 0.01 |
| 30-44 | 6067 | 3.33 (1.85-6.00) | < 0.01 | 1.53 (1.42-1.64) | < 0.01 |
| 45-59 | 10156 | 8.91 (5.13-15.48) | < 0.01 | 2.35 (2.19-2.52) | < 0.01 |
| 60-74 | 14000 | 26.45 (15.29-45.75) | < 0.01 | 3.83 (3.58-4.10) | < 0.01 |
| 75+ | 7028 | 62.63 (35.83-109.48) | < 0.01 | 6.43 (6.00-6.90) | < 0.01 |
| Year | |||||
| 1973-1985 | 5138 | Reference | Reference | ||
| 1986-1995 | 5551 | 0.71 (0.55-0.92) | < 0.01 | 0.75 (0.72-0.79) | < 0.01 |
| 1996-2005 | 13131 | 0.46 (0.36-0.58) | < 0.01 | 0.58 (0.56-0.60) | < 0.01 |
| 2006-2015 | 20472 | 0.42 (0.33-0.53) | < 0.01 | 0.42 (0.40-0.44) | < 0.01 |
| Race | |||||
| White | 36319 | Reference | Reference | ||
| Black | 3851 | 1.01 (0.75-1.36) | 0.934 | 1.09 (1.04-1.14) | < 0.01 |
| Other | 4007 | 1.01 (0.77-1.33) | 0.939 | 1.03 (0.98-1.08) | 0.223 |
| Unknown* | 115 | - | - | 0.55 (0.37-0.80) | < 0.01 |
| Sex | |||||
| Male | 24395 | Reference | Reference | ||
| Female | 19897 | 0.67 (0.57-0.79) | < 0.01 | 0.89 (0.87-0.91) | < 0.01 |
| SES | |||||
| Low | 18469 | Reference | Reference | ||
| Medium | 23087 | 1.11 (0.95-1.31) | 0.202 | 1.04 (1.01-1.07) | < 0.01 |
| High | 2736 | 1.42 (1.01-2.00) | 0.044 | 1.17 (1.11-1.24) | < 0.01 |
| Marriage | |||||
| Married | 24724 | Reference | Reference | ||
| Unmarried | 18286 | 1.56 (1.32-1.85) | < 0.01 | 1.13 (1.10-1.16) | < 0.01 |
| Unknown | 1282 | 1.42 (0.90-2.23) | 0.13 | 0.97 (0.89-1.05) | 0.443 |
Abbreviations: AML: acute myeloid leukemia; SES: socioeconomic status; *: hazard ratio is inapplicable, due to few observations in this category.