Table 2.

Univariate and Multivariate Cox Proportional-hazard Regression Analysis of Receipt of IOC or POC and Cancer Survival in CRC Patients with Stage II or III^a.

Characteristic	Univariate Analysis			Multivariate Analysis
	HR (95% CI)	P Value		HR (95% CI)	P Value
IOC		<0.001			<0.001
Did not receive	1.0 (Reference)			1.0 (Reference)
Received	0.33 (0.23-0.48)			0.30 (0.19-0.48)
POC		0.006			<0.001
Did not receive	1.0 (Reference)			1.0 (Reference)
Received	0.62 (0.45-0.87)			0.44 (0.30-0.64)
TNM stage		<0.001			<0.001
I-II	1.0 (Reference)			1.0 (Reference)
III-IV	2.52 (1.89-3.36)			2.35 (1.59-3.48)
Lymph node metastasis		<0.001			0.412
No	1.0 (Reference)			1.0 (Reference)
Yes	1.70 (1.28-2.25)			1.17 (0.80-1.72)
Age		0.995			0.998
< 50	1.0 (Reference)			1.0 (Reference)
≥ 50	0.99 (0.56-1.79)			1.00 (0.50-2.01)
Gender		0.368			0.769
Female	1.0 (Reference)			1.0 (Reference)
Male	0.88 (0.67-1.16)			1.05 (0.74-1.50)
Tumor location		0.694			0.991
Colon	1.0 (Reference)			1.0 (Reference)
Rectum	0.94 (0.70-1.27)			1.00 (0.70-1.44)
Tumor size		0.350			0.894
< 5 cm	1.0 (Reference)			1.0 (Reference)
≥ 5 cm	1.15 (0.86-1.52)			0.98 (0.69-1.38)
Differentiation		0.024			0.018
Good	1.0 (Reference)			1.0 (Reference)
Moderate or Poor	1.92 (1.09-3.36)			2.16 (1.14-4.06)

Abbreviations: CI, confidence interval; HR, hazard ratio. ^aPatients with TNM stage II or stage III cancer with typical carcinoma history were included in this analysis. ^bP < 0.05 was considered to indicate statistical significance.