Table 3.
Associations between Six SNPs and Telomere Length
| SNP | Genotype | Short TL, n (%) | Long TL, n (%) | OR (95% CI)a | P |
|---|---|---|---|---|---|
| POT1 rs727505 | GG | 109 (52.4) | 126 (57.8) | 1.00 | |
| AG | 89(42.8) | 80 (36.7) | 0.78 (0.52-1.16) | 0.213 | |
| AA | 10 (4.8) | 12 (5.5) | 1.04 (0.43-2.50) | 0.933 | |
| POT1 rs727506 | GG | 51 (24.5) | 58 (26.6) | 1.00 | |
| AG | 93 (44.7) | 102 (46.8) | 0.96 (0.60-1.54) | 0.880 | |
| AA | 64 (30.8) | 58 (26.6) | 0.80 (0.48-1.34) | 0.390 | |
| RTEL1 rs2297441 | GG | 85 (40.9) | 113 (51.8) | 1.00 | |
| AG | 99 (47.6) | 78(35.8) | 0.85 (0.46-1.57) | 0.596 | |
| AA | 24 (11.5) | 27 (12.4) | 0.59 (0.39-0.89) | 0.012 | |
| RTEL1 rs3208008 | AA | 83 (39.9) | 112 (51.4) | 1.00 | |
| AC | 102 (49.0) | 80 (36.7) | 0.75 (0.45-0.97) | 0.022 | |
| CC | 23 (11.1) | 26 (11.9) | 0.84 (0.45-1.57) | 0.581 | |
| PARP1 rs1136410 | AA | 89 (42.8) | 73 (33.5) | 1.00 | |
| AG | 94 (45.2) | 118 (54.1) | 1.53 (1.01-2.31) | 0.043 | |
| GG | 25 (12.0) | 27 (12.4) | 1.32 (0.70-2.46) | 0.389 | |
| PARP1 rs1805414 | GG | 117 (56.3) | 142 (65.1) | 1.00 | |
| AG | 75 (36.1) | 67 (30.7) | 0.74 (0.49-1.11) | 0.143 | |
| AA | 16 (7.7) | 9 (4.1) | 0.46 (0.20-1.09) | 0.077 |
TL: telomere length; aAdjusted for age and smoking status.