Table 1.
Characteristics of study participants.
| Variable | Mean (SD) or N (percent) |
|---|---|
| Age at death | 89.9 (6.4) |
| Education | 16.2 (3.6) |
| Female | 910 (68.9%) |
| Follow‐up years | 8.4 (5.0) |
| Baseline global cognition | −0.10 (0.61) |
| Global cognition proximate to death | −1.00 (1.19) |
| Final clinical diagnosis | |
| No cognitive impairment | 410 (31.0%) |
| Mild cognitive impairment | 307 (23.2%) |
| Alzheimer’s dementia | 583 (44.1%) |
| Other dementia | 21 (1.6%) |
| Pathologic AD (Reagan criteria) | 874 (66.2%) |
| Macroscopic infarctsa | 473 (35.8%) |
| Microscopic infarctsa | 392 (29.7%) |
| Cortical Lewy bodiesa | 175 (13.3%) |
| TDPb | 433 (32.8%) |
| Hippocampal sclerosisa | 132 (10.0%) |
| Cerebral amyloid angiopathyc | 491 (37.2%) |
| Atherosclerosisc | 429 (32.5%) |
| Arteriolosclerosisc | 413 (31.3%) |
a
Present.
b
TDP inclusions in limbic or neocortical regions.
c
Moderate or severe.