Table 1.
Demographic and clinical characteristics of 55 patients with MS included in the study.
| Characteristics |
RRMS (n = 22) |
SPMS (n = 16) |
PPMS (n = 17) |
|---|---|---|---|
| Sex, n (%) | |||
| Female | 15 (68) | 13 (81) | 12 (71) |
| Male | 7 (32) | 3 (19) | 5 (29) |
| Age (years), mean ± SD | 43.0 ± 10.7 | 56.7 ± 7.5 | 54.1 ± 8.2 |
| Disease duration from symptoms onset (years), mean ± SD | 10.4 ± 8.4 | 27.2 ± 11.8 | 12.4 ± 5.9 |
| Expanded disability status scale score, median (range) | 3 (1.5–6) | 6 (2.5–6.5) | 6 (3–7.5) |
| T2 lesion volume (ml), median (interquartile range) | 9.5 (4.4–17.9) | 20.2 (6.1–32.7) | 8.0 (5.2–14.2) |
| DBSI‐derived metrics in brain white matter lesions | |||
| Fiber fraction, median (interquartile range) | 0.40 (0.38–0.42) | 0.39 (0.37–0.47) | 0.37 (0.32–0.41) |
| Isotropic restricted fraction, median (interquartile range) | 0.07 (0.07–0.08) | 0.06 (0.04–0.07) | 0.07 (0.05–0.08) |
| Isotropic nonrestricted fraction, median (interquartile range) | 0.43 (0.40–0.47) | 0.46 (0.39–0.50) | 0.48 (0.43–0.53) |
| Radial diffusivity (μm2/msec), median (interquartile range) | 0.70 (0.65–0.74) | 0.68 (0.64–0.71) | 0.70 (0.66–0.74) |
| Axial diffusivity (μm2/msec), median (interquartile range) | 1.84 (1.74–1.97) | 1.92 (1.83–2.02) | 1.99 (1.79–2.11) |
| DBSI‐derived metrics in normal‐appearing corpus callosum | |||
| Fiber fraction, median (interquartile range) | 0.61 (0.58–0.66) | 0.60 (0.54–0.68) | 0.61 (0.58–0.66) |
| Isotropic restricted fraction, median (interquartile range) | 0.19 (0.18–0.21) | 0.16 (0.12–0.19) | 0.20 (0.17–0.23) |
| Isotropic nonrestricted fraction, median (interquartile range) | 0.04 (0.00–0.10) | 0.04 (0.02–0.15) | 0.05 (0.03–0.07) |
| Radial diffusivity (μm2/msec), median (interquartile range) | 0.31 (0.20–0.35) | 0.30 (0.20–0.34) | 0.33 (0.29–0.38) |
| Axial diffusivity (μm2/msec), median (interquartile range) | 2.25 (2.12–2.36) | 2.13 (2.02–2.24) | 2.11 (2.06–2.25) |
RRMS, relapsing‐remitting multiple sclerosis; SPMS, secondary‐progressive multiple sclerosis; PPMS, primary‐progressive multiple sclerosis; DBSI, diffusion basis spectrum imaging.