Table 1.
Top hits for genome-wide case–control association analysis of apparent treatment-resistant hypertension
| rs# | CHR | A1/A2 | EAF | OR | 95% CI | P-value | Direction* | Location | Gene(s) |
|---|---|---|---|---|---|---|---|---|---|
| 228 AA cases | |||||||||
| 2,490 normotensive* | |||||||||
| rs76967376 | 18 | A/C | 0.11 | 2.65 | 1.87, 3.78 | 5.75E-08 | +++++ | Intronic | MYO5B |
| rs185169399 | 5 | A/G | 0.94 | 11.96 | 4.53, 31.55 | 5.27E-07 | +++?+ | Intergenic | CDH18 |
| rs114349263 | 5 | A/C | 0.06 | 0.08 | 0.03, 0.22 | 5.52E-07 | ---?- | Intergenic | CDH18 |
| rs12665245 | 6 | T/C | 0.86 | 0.36 | 0.24, 0.54 | 1.34E-06 | ----? | Intronic | ENPP3 |
| rs143255889 | 10 | C/G | 0.07 | 3.10 | 1.95, 4.92 | 1.80E-06 | +++++ | Intergenic | LINC01519 |
| 1,817 hypertensive* | |||||||||
| rs138399316 | 6 | T/C | 0.15 | 5.85 | 3.00, 11.37 | 1.89E-07 | ++?+? | Intronic | BPHL |
| rs146183009 | 1 | A/G | 0.11 | 2.49 | 1.75, 3.54 | 4.41E-07 | +++++ | Intronic | ICMT |
| rs111285947 | 17 | A/G | 0.06 | 3.89 | 2.21, 6.83 | 2.16E-06 | +?++? | Downstream | LINC00670 |
| rs1651805 | 19 | C/G | 0.26 | 1.84 | 1.43, 2.36 | 2.17E-06 | +++++ | Intergenic | LSM14A,KIAA0355 |
| rs114511751 | 1 | T/C | 0.10 | 2.44 | 1.68, 3.53 | 2.20E-06 | +++++ | Intronic | TMCC2 |
| 931 EA cases | |||||||||
| 14,201 normotensive* | |||||||||
| rs12046278 | 1 | T/C | 0.63 | 0.71 | 0.63, 0.80 | 1.11E-08 | ------------? | Intronic | CASZ1 |
| rs34071855 | 1 | C/G | 0.64 | 0.72 | 0.64, 0.81 | 4.87E-08 | ------------+ | Intronic | CASZ1 |
| rs11674660 | 2 | T/C | 0.15 | 1.53 | 1.31, 1.80 | 7.63E-08 | +++-+++-+++-+ | Intergenic | DNMT3A,DTNB |
| rs17035646 | 1 | A/G | 0.35 | 1.36 | 1.26,1.59 | 7.90E-08 | ++++++++++++- | Intronic | CASZ1 |
| rs880315 | 1 | T/C | 0.65 | 0.74 | 0.66, 0.83 | 1.19E-07 | ------------+ | Intronic | CASZ1 |
| 5,266 hypertensive* | |||||||||
| rs74725390 | 7 | T/C | 0.07 | 1.70 | 1.38, 2.09 | 5.36E-07 | +++-+-+++-+? | Intergenic | COBL,POM121L12 |
| rs12050053 | 13 | T/G | 0.06 | 2.43 | 1.71, 3.47 | 8.39E-07 | ++???+?++??? | Intergenic | EEF1DP3,FRY-AS1 |
| rs4844662 | 1 | C/G | 0.47 | 1.31 | 1.18, 1.47 | 9.01E-07 | +++-++++-+++ | Intronic | PLXNA2 |
| rs111281682 | 7 | A/G | 0.83 | 0.72 | 0.63, 0.82 | 1.63E-06 | +----++----- | Intergenic | MYL10,CUX1 |
| rs77270397 | 13 | A/G | 0.07 | 2.09 | 1.54, 2.82 | 1.75E-06 | ++???+-+++?? | Intergenic | EEF1DP3,FRY-AS1 |
AA order: ARIC, HyperGEN, JHS, PHG, MESA. EA order: normotensive, AFTER-EU, AGES, ARIC, HyperGEN, NEO, CHS, HVH1 cases, HVH1 controls, HVH2 cases, HVH2 controls, PROSPER, FHS, MESA. EA order: treatment responsive, AFTER-EU, AGES, ARIC, HyperGEN, NEO, CHS, HVH1 cases, HVH1 controls, HVH2 cases, HVH1 controls, PROSPER, MESA. Significant P-value after correction for multiple testing <5 × 10−8. Abbreviations: AA, African American, EA, European American, EAF, effect allele frequency; OR, odds ratio; CI, confidence interval; A1, allele 1, effect allele; A2, allele 2.
*Controls.