Table 1.
Clinical characteristics of subjects (n = 937) according to the location of cerebral WMH.
| PVWMH | p | DSWMH | p | |||
|---|---|---|---|---|---|---|
| None or mild (n = 677) | Moderate to severe (n = 260) | None or mild (n = 681) | Moderate to severe (n = 256) | |||
| Gender (male, %) | 263 (38.8) | 91 (35.0) | 0.277 | 267 (39.2) | 87 (34.0) | 0.142 |
| Age, year | 64.8 ± 6.2 | 70.0 ± 5.8 | <0.001 | 65.2 ± 6.4 | 68.9 ± 5.9 | <0.001 |
| Hypertension (%) | 362 (53.5) | 188 (72.3) | <0.001 | 372 (54.6) | 178 (69.5) | <0.001 |
| Diabetes mellitus (%) | 138 (20.4) | 82 (31.5) | <0.001 | 157 (23.1) | 63 (24.6) | 0.617 |
| Hypercholesterolemia (%) | 234 (34.6) | 73 (28.1) | 0.058 | 219 (32.2) | 88 (34.4) | 0.519 |
| Current smoking status (%) | 134 (19.8) | 50 (19.2) | 0.846 | 136 (20.0) | 48 (18.8) | 0.675 |
| CAOD (%) | 33 (4.9) | 20 (7.7) | 0.095 | 41 (6.0) | 12 (4.7) | 0.431 |
| Statin medication (%) | 175 (25.8) | 47 (18.1) | 0.012 | 169 (24.8) | 53 (20.7) | 0.187 |
| SBP, mmHg | 131.6 ± 17.1 | 135.9 ± 20.6 | 0.004 | 131.6 ± 17.5 | 136.0 ± 19.6 | 0.001 |
| DBP, mmHg | 80.0 ± 11.1 | 81.0 ± 12.4 | 0.212 | 79.8 ± 10.9 | 81.6 ± 12.7 | 0.037 |
| Glucose, mg/dL | 125.8 ± 48.3 | 128.7 ± 52.7 | 0.430 | 127.6 ± 48.3 | 124.1 ± 53.0 | 0.332 |
| Total cholesterol, mg/dL | 193.4 ± 39.7 | 192.4 ± 43.5 | 0.740 | 193.5 ± 40.2 | 192.2 ± 42.4 | 0.671 |
| Triglyceride, mg/dL | 150.5 ± 93.8 | 159.5 ± 113.26 | 0.214 | 153.7 ± 103.7 | 151.2 ± 88.1 | 0.734 |
| eGFR, ml/min/1.73 m2 | 75.8 ± 16.3 | 68.3 ± 18.0 | <0.001 | 75.0 ± 17.2 | 70.4 ± 16.4 | <0.001 |
| Hcyt, IU/L | 10.4 ± 4.2 | 12.3 ± 5.9 | <0.001 | 10.7 ± 4.3 | 11.6 ± 5.7 | 0.016 |
CAOD, coronary arterial occlusive disease; SBP, systolic blood pressure; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; Hcyt, plasma total homocysteine; OR, odds ratio; CIs, confidence intervals.