Table 3.

Logistic regression analysis of moderate to severe PVWMH and DSWMH based on plasma Hcyt quartiles.

	Moderate to severe PVWMH		Moderate to severe DSWMH
	OR (95% CIs)	p*	OR (95% CIs)	p*
Q1 (<8.13 IU/L)	Ref	–	Ref	–
Q2 (8.13–9.99 IU/L)	0.62 (0.37–1.03)	0.067	1.14 (0.72–1.79)	0.582
Q3 (10.00–12.08 IU/L)	1.24 (0.76–2.02)	0.390	1.15 (0.96–0.98)	0.566
Q4 (>12.08 IU/L)	2.50 (1.44–4.34)	0.001	1.34 (0.79–2.28)	0.272

Q1, Q2, Q3 and Q4 represent the quartile groups of plasma Hcyt level.

^*Analyze after adjusting confounding factors (sex, age, hypertension, diabetes mellitus, hypercholesterolemia, current smoking status, coronary arterial occlusive disease, current statin medication, and estimated glomerular filtration rate).

Ref represents the first quartile Hcyt group (Q1) as a reference group for analyses.

PVWMH, periventricular white matter hyperintensities; DSWMH, deep subcortical white matter hyperintensities; OR, odds ratio; CI, confidence interval.