Table 5.

Results of the multinomial logistic regression analysis of subjects with pred-PVWMH and pred-DSWMH.

	No WMH	Pred-PVWMH		Pred-DSWMH		Both PVWMH and DSWMH
	OR (95% CIs)	OR (95% CIs)	p*	OR (95% CIs)	p*	OR (95% CIs)	p*
Age	Ref	1.12 (1.08–1.17)	<0.001	1.04 (1.00–1.08)	0.085	1.14 (1.11–1.17)	<0.001
Gender (male)	Ref	0.88 (0.52–1.48)	0.620	1.21 (0.64–2.27)	0.564	1.49 (1.00–1.20)	0.049
Hypertension	Ref	0.75 (0.48–1.18)	0.210	1.37 (0.82–2.30)	0.232	1.70 (1.22–2.37)	0.002
Diabetes mellitus	Ref	1.47 (0.87–2.49)	0.148	0.98 (0.51–1.89)	0.956	1.53 (1.04 0 2.24)	0.031
Hypercholesterolemia	Ref	1.10 (0.56–2.18)	0.781	0.90 (0.40–2.02)	0.798	1.20 (0.73–1.96)	0.468
Current smoking status	Ref	0.86 (0.47–1.57)	0.616	0.89 (0.42–1.89)	0.760	1.15 (0.73–1.78)	0.551
CAOD	Ref	1.40 (0.62–3.16)	0.424	NA	–	0.67 (0.33–1.36)	0.271
Statin medication	Ref	0.68 (0.32–1.45)	0.323	0.93 (0.38–2.25)	0.863	0.66 (0.39–1.13)	0.131
eGFR	Ref	0.99 (0.98–1.01)	0.188	0.99 (0.97–1.00)	0.082	1.00 (0.98–1.01)	0.304
Hcyt	Ref	1.08 (1.03–1.14)	0.005	0.95 (0.87–1.04)	0.274	1.08 (1.03–1.13)	0.001

^*Analysis after adjusting for confounding factors (sex, age, hypertension, diabetes mellitus, hypercholesterolemia, current smoking status, CAOD, current statin medication, estimated glomerular filtration rate, and plasma total homocysteine level).

No WHH group was regarded as reference (Ref) for analysis. NA means not available because there was no case of CAOD in the pred-DSWMH group.

CAOD, coronary arterial occlusive disease; Hcyt, plasma total homocysteine; OR, odds ratio; CIs, confidence intervals.