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. 2019 Nov 5;10:1382. doi: 10.3389/fphys.2019.01382

FIGURE 2.

FIGURE 2

Determinants of exercise dysfunction in CF and age-related factors which may affect exercise capacity through the lifespan in CF (A). Airways in CF may be altered in structure from fetal development or from destructive events, leading to airway malacia. The incidence and severity of factors involved in CF Pathology increase over the lifespan of people with CF, as indicated by the progression from light yellow to dark orange across the lifespan in (A). Projected age-related decline in aerobic capacity (i.e., V˙O2max) for healthy populations (solid green line, adapted from Shvartz and Reibold (1990) and Booth and Zwetsloot (2010), and hypothetical age-related declines in aerobic fitness for current (dashed blue line) and future (dotted red line) CF populations (B). It is possible that with early initiation of CFTR modulator therapy and effective disease management, that in the future, individuals with CF may possess aerobic capacities more similar to healthy controls than individuals with CF today.