Figure 4.

Schematic representation of post-natal adrenal cortex centripetal streaming and self-renewal in mice. Gli1⁺ cells in the capsule can give rise to Sf1⁺/Shh⁺ cortical cells: both are self-renewing adrenocortical progenitor cell populations. Shh⁺ cells can become ZG cells, and ZG cells can lineage convert to ZF cells, which migrate centripetally. Direct differentiation between Shh⁺ cells and ZF is probably occurring in parallel. These differentiation events are governed by pathways mostly active in the capsular/subcapsular region, while apoptotic figures are observed at the cortex/medulla boundary in senescence cells.