Table 6.

Parameters of human SP-A binding to murine alveolar macrophages.

	SP-A1			SP-A2
Genotype	Bmax	Kd (nM)	h	Bmax	Kd (nM)	h
SP-A+/+	3.60 ± 1.32	5.14 ± 3.13	1.88 ± 2.3	16.57 ± 1.30	5.00 ± 0.70	1.88 ± 0.49
SP-A−/−	No binding	–	–	8.43 ± 1.40	7.04 ± 3.00	0.93 ± 0.20
SP-A−/−,Sftpa2(1A0)	5.60 ± 0.54	5.29 ± 0.17	1.76 ± 0.47	20.37 ± 1.31	5.00 ± 0.67	1.36 ± 0.22
SP-A−/−,Sftpa1(6A2)	6.84 ± 1.45	12.96 ± 7.01	0.89 ± 0.17	8.10 ± 0.45	2.80 ± 0.47	1.25 ± 0.21
	SP-A1+EDTA			SP-A2+EDTA
SP-A+/+	No binding	–	–	3.00 ± 0.42	9.20 ± 2.52	1.29 ± 0.27
SP-A−/−	No binding	–	–	2.50 ± 0.28	10.82 ± 2.04	1.53 ± 0.26
SP-A−/−,Sftpa2(1A0)	1.19 ± 0.33	17.63 ± 9.85	1.07 ± 0.23	5.32 ± 1.60	21.40 ± 11.95	1.14 ± 0.23
SP-A−/−,Sftpa1(6A2)	1.66 ± 0.62	26.20 ± 21.13	0.92 ± 0.19	2.60 ± 0.28	10.26 ± 2.16	1.24 ± 0.17