Table 2.
Top 10 related candidate diseases of ciprofloxacin, ceftriaxone, ofloxacin, ampicillin and cefotaxime.
| Drug name | Rank | Disease name | Description | Rank | Disease | Description |
|---|---|---|---|---|---|---|
| ciprofloxacn | 1 | Pneumonia, Bacterial | CTD | 6 | Gram-Positive Bacterial Infections | CTD |
| 2 | Salmonella Infections | CTD | 7 | Eye Infections, Bacterial | Literature (Marino et al., 2013) | |
| 3 | Bacterial Infections | CTD | 8 | Soft Tissue Infections | CTD | |
| 4 | Streptococcal Infections | DrugBank | 9 | Enterobacteriaceae Infections | CTD | |
| 5 | Gram-Negative Bacterial Infections | CTD | 10 | Helicobacter Infections | CTD | |
| ceftriaxone | 1 | Gram-Negative Bacterial Infections | CTD | 6 | Haemophilus Infections | CTD |
| 2 | Bacterial Infections | CTD, ClinicalTrials |
7 | Gram-Positive Bacterial Infections | CTD | |
| 3 | Septicemia | DrugBank | 8 | Skin Diseases, Infectious | DrugBank | |
| 4 | Respiratory Tract Infections | CTD | 9 | Wound Infection | ClinicalTrials | |
| 5 | Pseudomonas Infections | DrugBank | 10 | Eye Infections, Bacterial | DrugBank | |
| ofloxacin | 1 | Eye Infections, Bacterial | ClinicalTrials, DrugBank |
6 | Pseudomonas Infections | CTD |
| 2 | Gram-Negative Bacterial Infections | DrugBank | 7 | Bacterial Infections | CTD | |
| 3 | Sinusitis | CTD | 8 | Bacteroides Infections | DrugBank | |
| 4 | Streptococcal Infections | CTD | 9 | Gram-Positive Bacterial Infections | CTD | |
| 5 | Pneumonia, Bacterial | CTD | 10 | Enterobacteriaceae Infections | DrugBank | |
| ampicillin | 1 | Pseudomonas Infections | unconfirmed | 6 | Proteus Infections | CTD |
| 2 | Bacterial Infections | CTD | 7 | Septicemia | DrugBank | |
| 3 | Gram-Positive Bacterial Infections | CTD | 8 | Streptococcal Infections | CTD | |
| 4 | Gram-Negative Bacterial Infections | CTD | 9 | Wound Infection | CTD | |
| 5 | Pneumonia, Bacterial | CTD, ClinicalTrials | 10 | Enterobacteriaceae Infections | DrugBank | |
| cefotaxime | 1 | Respiratory Tract Infections | CTD, ClinicalTrials | 6 | Enterobacteriaceae Infections | DrugBank |
| 2 | Pseudomonas Infections | DrugBank | 7 | Gram-Positive Bacterial Infections | CTD, DrugBank | |
| 3 | Gram-Negative Bacterial Infections | CTD, DrugBank | 8 | Wound Infection | DrugBank | |
| 4 | Septicemia | DrugBank | 9 | Skin Diseases, Infectious | ClinicalTrials | |
| 5 | Bacterial Infections | CTD, ClinicalTrials | 10 | Osteomyelitis | CTD, ClinicalTrials |
(1) CTD refers to the Comparative Toxicogenomics Database (CTD), which contains a manually managed drug-disease association. (2) DrugBank refers to the drug-disease association held in the DrugBank database, which collects experimental information of the drug. (3) ClinicalTrials means that the association of drugs with the disease is recorded in the online database ClinicalTrials.gov. (4) literature refers to the literature supporting the association of drugs with the disease. (5) unconfirmed means that there is no evidence that the drug is associated with the disease.