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. 2019 Sep 10;86(5):780–792. doi: 10.1002/ana.25585

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© 2019 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Human white matter (WM) and gray matter (GM) astrocyte subtypes differ in morphology and transcriptome. (A, B) Immunostaining showed expression of astrocyte markers CD44 and SOX9 in control human induced pluripotent stem cell (hiPSC)‐derived WM (A) and GM astrocytes (B). Scale bars = 100μm. (C) Volcano plot of differential expression analysis of control human WM astrocytes and human GM astrocytes shows significant differentially expressed genes (DEGs) in red. The 15 most significantly up‐ or downregulated DEGs are labeled. (D) Significantly enriched Gene Ontology (GO) terms per molecular function classified the DEGs into different categories.