A3.

Response evaluation of preoperative adjuvant therapy (TRG)

TRG	Description
TRG, tumor regression grading. Tumor regression grading can only be assessed in primary tumors; Cancer cells refer to surviving cancer cells, excluding degenerative and necrotic cells; c. Presence of tumor-free mucus lake after neoadjuvant therapy should not be considered as residual cancer.
0 (Complete response)	No cancer cells, including lymph nodes
1 (Moderately response)	Single cells or small groups of residual cancer cells
2 (Minimal response)	Residual cancer is outgrown by fibrosis
3 (Poor response)	Extensive residual cancer cells; minimal or no treatment effect