3.

Clinical and combined nomograms with calibration curves. (A) Clinical nomogram included only the significant clinical parameters (AFP, BCLC-stage, capsule integrity, tumor margin and enhancing capsule); (B) Combined nomogram included all significant clinical factors and texture signature. Locate each variate on the corresponding axis, draw an upward vertical line to the Points axis for the number of points, add all of single point as a total point, and draw a line straight down from the total points axis to the risk axis to determine the high Ki-67 status probability. Calibration curves of both clinical nomogram (C) and combined nomogram (D) depicted good agreement between the predicted and pathologically confirmed Ki-67 status in HCC patients with dotted line (actual calibration) closed to dashed line (perfect calibration) and P>0.05 in Hosmer-Lemeshow test. AFP, alpha-fetoprotein; BCLC, Barcelona-Clinic Liver Cancer.