S3.

Features and formulas of T2W, PRE and AP and PVP signatures

Variables	Selected features	Formulas
T2W, T2-weighted; PRE, pre-contrast; AP, arterial phase; PVP, portal venous phase.
T2W	Kurtosis GLCMEnergy_AllDirection_offset4_SD InverseDifferenceMoment_AllDirection_offset1_SD	T2W_signature =0.283366555354594−0.23819622697206×kurtosis +23527.55867767 ×GLCMEnergy_AllDirection_offset4_SD +2682.38755674699 ×InverseDifferenceMoment_AllDirection_offset1_SD
PRE	GLCMEntropy_AllDirection_offset1_SD InverseDifferenceMoment_AllDirection_offset1_SD HighGreyLevelRunEmphasis_AllDirection_offset7_SD	PRE_signature =−0.52911653747402+47.9146167639774 ×GLCMEntropy_AllDirection_offset1_SD +1605.36995629506 ×InverseDifferenceMoment_AllDirection_offset1_SD +0.00040882674205247 ×HighGreyLevelRunEmphasis_AllDirection_offset7_SD
AP	Correlation_angle45_offset7 ShortRunEmphasis_AllDirection_offset1_SD ShortRunEmphasis_AllDirection_offset7_SD	AP_signature =−0.00842138061108291+23.921329140764 ×Correlation_angle45_offset7+1127.92265386803 ×ShortRunEmphasis_AllDirection_offset1_SD +11883.6424629131 ×ShortRunEmphasis_AllDirection_offset7_SD
PVP	GLCMEntropy_angle45_offset7 Inertia_angle90_offset1 LongRunHighGreyLevelEmphasis_AllDirection_ offset7_ SDLongRunLowGreyLevelEmphasis_AllDirection_ offset7_SD	PVP_signature =0.352513703210956-0.0330303304468419 ×GLCMEntropy_angle45_offset7 +0.0023251740213394×Inertia_angle90_offset1 −1.5035989491621×10−9 ×LongRunHighGreyLevelEmphasis_AllDirection_offset7_SD +5099944.76648665 ×LongRunLowGreyLevelEmphasis_AllDirection_offset7_SD