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. 2019 Oct;96(4):871–882. doi: 10.1016/j.kint.2019.04.040

Figure 5.

Figure 5

Mature glomeruli formed in vivo after implanting human pluripotent stem cell–derived kidney precursor cells. Glomerular tufts immunostain (brown) for the podocyte marker synaptopodin. Glomeruli immunostain for collagen α3 (IV) and vascular endothelial growth factor A (VEGFA). Capillaries that immunostain for platelet endothelial cell adhesion molecule (PECAM) are detected inside the glomerular tuft. Nuclei in the collagen α3 (IV) and PECAM frames are counterstained with hematoxylin. Bar = 50 μm. Images are adapted from Bantounas I, Ranjzad P, Tengku F, et al. Generation of functioning nephrons by implanting human pluripotent stem cell-derived kidney progenitors. Stem Cell Reports. 2018;10:766–77923 via Creative Commons Attribution License (CC BY). To optimize viewing of this image, please see the online version of this article at www.kidney-international.org.