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. 2019 Oct 19;10(25):6414–6421. doi: 10.7150/jca.32251

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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Overexpression of LINC00261 decreased NSCLC cell proliferation migration and invasion (a) LINC00261 expression in cancer cells transduced with empty vector (control) or LINC00261 virus (LINC00261) was detected by RT-qPCR. β-actin was used as an internal control. (b) Edu assay showed that overexpression of LINC00261 significantly decreased cell proliferation in A549 cancer cells. (c) Edu assay showed that knockdown of LINC00261 significantly decreased cell proliferation in SPCA1 cancer cells. (d) Colony formation assay demonstrated that oncogenic survival of cancer cells in LINC00261 group was significantly decreased compared with control group. (e) Wound healing assay showed that the migrated ability was obviously inhibited in LINC00261 group compared with control group. (f) Transwell assay showed that number of invaded cells in LINC00261 group was obviously reduced compared with control group. The results represent the average of three independent experiments (mean ± standard error of the mean). *P<0.05, as compared with the control cells.