Table 3.
Univariate and multivariate analyses of factors associated with cumulative recurrence rate.
| Factors | Univariate, p | Multivariate | p value | |
|---|---|---|---|---|
| HR | 95%Cl | |||
| Sex (female vs. male) | 0.245 | NA | ||
| Age (years) (≥53 vs. <53) | 0.285 | NA | ||
| HBsAg (positive vs. negative) | 0.483 | NA | ||
| Child-Pugh classification (A vs. B) | 0.879 | NA | ||
| Serum ALT, U/L (≥75 vs. <75) | 0.838 | NA | ||
| Serum AFP, ng/L (≥20 vs. <20) | 0.099 | NA | ||
| Liver cirrhosis (yes vs. no) | 0.176 | NA | ||
| Tumor size (diameter, cm) (≥5 vs. <5) | <0.001 | 0.549 | 0.368-0.819 | 0.003 |
| Tumor number (multiple vs. single) | 0.005 | NS | ||
| Tumor Capsulation (yes vs. no) | 0.051 | NA | ||
| Tumor differentiation (III/IV vs. I/II.) | 0.078 | NA | ||
| Microvascular invasion (yes vs. no) | <0.001 | 1.736 | 1.140-2.644 | 0.010 |
| TNM stage (I/II vs. III/IV) | 0.002 | NA | ||
| CD151 expression (low vs. high) | <0.001 | 0.532 | 0.354-0.799 | 0.002 |
| Mortalin expression (low vs. high) | 0.003 | 0.664 | 0.444-0.992 | 0.046 |
| CD151/Mortalin expression (low vs. high) | <0.001 | 0.626 | 0.421-0.932 | 0.021 |
Abbreviation: 95% CI, 95% confidence interval; AFP, alpha-fetoprotein; TNM, tumor-node-metastasis; HBsAg, hepatitis B surface antigen; HR, hazard ratio; NA, not adopted; NS, not significant; OS, overall survival. Cox proportional hazards regression model.