Figure 3.

Disease-state development for whole group of patients from Germany (n=1587) with PLGG. Stacked-plot of disease-state development over first 10 years after diagnosis for the whole group of patients with PLGG, starting from date of diagnosis. State-probabilities derived from the multistate model of Figure 2. Exact numbers given for state-probabilities at time point 5 years after diagnosis. State 1: no intervention. State 2: first surgery without prior adjuvant therapy. State 3: two or more surgeries without prior adjuvant therapy. State 4: first adjuvant therapy. State 5: one or more surgeries after first adjuvant therapy. State 6: two or more adjuvant therapies. State 7: death of any cause. Levels of progressiveness: non-progressive (states 1 and 2), low progressive (states 3 and 4), and highly progressive (states 5 and 6) PLGG.