Figure 4.

Disease-state development for patients with PLGG by subgroup age-group.Stacked-plot of disease-state development over first 10 years after diagnosis for the subgroup age-group, starting from date of diagnosis: (A) Infant-age < 1 year at diagnosis, (B) 1-7^11/12 years at diagnosis, and (C) ≥ 8 years at diagnosis. State-probabilities derived from the multistate model of Figure 2. Exact numbers given for state-probabilities at time point 5 years after diagnosis. State 1: no intervention. State 2: first surgery without prior adjuvant therapy. State 3: two or more surgeries without prior adjuvant therapy. State 4: first adjuvant therapy. State 5: one or more surgeries after first adjuvant therapy. State 6: two or more adjuvant therapies. State 7: death of any cause. Levels of progressiveness: non-progressive (states 1 and 2), low progressive (states 3 and 4), and highly progressive (states 5 and 6) PLGG.