Table 1.
Demographic and clinical characteristics of German patients with pediatric low-grade glioma (n=1587)
| median | (min / max) | |
|---|---|---|
| Age at diagnosis [years] | 7.60 | (0.10 / 17.90) |
| Age-group at diagnosis [years] | total (n) | (%) |
| <1 | 75 | (4.7) |
| 1-711/12 | 748 | (47.1) |
| ≥ 8 | 764 | (48.1) |
| Sex | ||
| Female | 740 | (46.6) |
| Male | 847 | (53.4) |
| Main location at diagnosis | ||
| Cerebral hemispheres | 320 | (20.2) |
| Supratentorial midline | 580 | (36.6) |
| Cerebellum | 467 | (29.4) |
| Caudal brain stem | 119 | (7.5) |
| Spinal cord | 56 | (3.5) |
| Lateral ventricles | 44 | (2.8) |
| Initially disseminated | 1 | (0.1) |
| Main histology at diagnosis | ||
| Pilocytic Astrocytoma WHO I | 869 | (54.8) |
| Diffuse Astrocytoma WHO II | 136 | (8.6) |
| Oligodendroglioma WHO II | 4 | (0.3) |
| Oligoastrocytoma WHO II | 8 | (0.5) |
| Neuronal and mixed neuronal-glial tumors | 203 | (12.8) |
| Low-grade neuroepithelial or glial lesions not otherwise specified [LGG-NOS] | 63 | (4.0) |
| No histology/radiologic diagnosis-only | 304 | (19.2) |
| Neurofibromatosis [NF] status | ||
| NF negative | 1352 | (85.2) |
| NF-1 | 233 | (14.7) |
| NF-2 | 2 | (0.1) |
| Tuberous sclerosis complex [TSC] | ||
| TSC negative | 1561 | (98.4) |
| TSC positive* | 26 | (1.6) |
| Extent of resection at 1st surgery (n=1283) | ||
| Complete resection | 522 | (32.9) |
| Subtotal resection | 138 | (8.7) |
| Partial resection | 360 | (22.7) |
| Biopsy-only | 263 | (16.6) |
1587 patients with pediatric low-grade glioma [PLGG] treated in Germany between 01.04.2004 and 31.03.2012 and followed until 27.04.2016 in the International Society of Paediatric Oncology - Low Grade Glioma subcommittee [SIOP-LGG] 2004 study. The percentage (%) of patients is given in brackets in respect to the whole group. * treatment with everolimus for subependymal giant cell astrocytoma in TSC patients was not documented, they remained in the observation group.