Table 1.
Characteristics of 13 genes methylation between HBV-positive carcinoma tissues and HBV-negative carcinoma tissues in HCC
| Gene | Studies (n) | Overall OR (95% CI) |
I2 | P value | HBV-positive carcinoma tissues/HBV-negative carcinoma tissues |
|---|---|---|---|---|---|
| p16 | 24 | 2.87 [2.05, 4.01] | 49% | <0.00001 | 708/224 |
| RASSF1A | 18 | 2.05 [1.44, 2.92] | 46% | <0.0001 | 914/228 |
| GSTP1 | 12 | 2.50 [1.52, 4.12] | 0% | 0.0003 | 234/129 |
| APC | 10 | 1.87 [1.11, 3.14] | 0% | 0.02 | 342/120 |
| RUNX3 | 8 | 1.32 [0.81, 2.16] | 0% | 0.27 | 292/104 |
| p14 | 6 | 1.75 [0.93, 3.29] | 39% | 0.08 | 191/93 |
| WIF1 | 6 | 0.73 [0.43, 1.25] | 0% | 0.25 | 430/62 |
| CDH1 | 6 | 1.01 [0.61, 1.67] | 56% | 0.96 | 255/111 |
| PRDM2 | 6 | 1.61 [0.81, 3.20] | 15% | 0.17 | 156/51 |
| p15 | 6 | 2.66 [1.25, 5.64] | 0% | 0.01 | 103/55 |
| SOCS1 | 5 | 1.60 [0.75, 3.45] | 8% | 0.23 | 58/52 |
| SFRP1 | 4 | 3.43 [1.19, 9.88] | 0% | 0.02 | 65/60 |
| MGMT | 3 | 1.46 [0.62, 3.45] | 0% | 0.39 | 114/41 |