Table 2.
Characteristics of eight genes methylation between HBV-positive adjacent tissues and HBV-negative adjacent tissues in HCC
| Gene | Studies (n) | Overall OR (95% CI) |
I2 | P value |
HBV-positive adjacent tissues/HBV-negative adjacent tissues |
|---|---|---|---|---|---|
| p16 | 10 | 1.39 [0.71, 2.71] | 0% | 0.33 | 274/103 |
| GSTP1 | 6 | 2.54 [1.04, 6.21] | 0% | 0.04 | 84/63 |
| RASSF1A | 3 | 0.94 [0.08, 11.22] | 63% | 0.96 | 63/29 |
| APC | 3 | 0.62 [0.07, 5.28] | 0% | 0.66 | 21/24 |
| RUNX3 | 3 | 3.07 [0.40, 23.77] | 0% | 0.28 | 21/24 |
| SOCS1 | 3 | 1.79 [0.20, 16.36] | 72% | 0.61 | 39/36 |
| CDH1 | 3 | 0.91 [0.35, 2.36] | 11% | 0.85 | 78/44 |
| SFRP1 | 3 | 1.86 [0.40, 8.62] | 0% | 0.43 | 40/55 |