Figure 12.

JSD-induced reversion of EMT depends on activation of AKT/GSK-3β signaling in vivo. Immunohistochemical staining was performed in tumor foci of mice to detect the expressions of E-cad, N-cad, and Vimentin. Pictures of immunohistochemical staining of E-cad (A), N-cad (C) and Vimentin (E) are shown. (B) The IOD of E-cad stain. (D) The IOD of N-cad stain. (F) The IOD of Vimentin stain. Compared with NC-control group, ***P<0.001; compared with si-AKT1-control group, #P<0.05, ##P<0.01; compared with oe-AKT1-control group, ●●●P<0.001; compared between NC-groups and si-AKT1-groups, ▼▼P<0.01, ▼▼▼P<0.001; compared between NC-groups and oe-AKT1-groups, ▲▲▲P<0.001; n=6.