Table 1.
Associations between H19 polymorphisms and neuroblastoma susceptibility
| Genotype | Cases (N=700) |
Controls (N=1514) |
P a | Crude OR (95% CI) |
P | Adjusted OR (95% CI) b |
P b |
|---|---|---|---|---|---|---|---|
| rs2839698 G>A (HWE=0.406) | |||||||
| GG | 331 (47.29) | 704 (46.50) | 1.00 | 1.00 | |||
| AG | 300 (42.86) | 667 (44.06) | 0.96 (0.79-1.16) | 0.646 | 0.96 (0.79-1.16) | 0.658 | |
| AA | 69 (9.86) | 143 (9.45) | 1.03 (0.75-1.41) | 0.871 | 1.04 (0.76-1.43) | 0.805 | |
| Additive | 0.858 | 0.99 (0.86-1.14) | 0.900 | 1.00 (0.87-1.14) | 0.956 | ||
| Dominant | 369 (52.71) | 810 (53.50) | 0.730 | 0.97 (0.81-1.16) | 0.730 | 0.97 (0.81-1.16) | 0.762 |
| Recessive | 631 (90.14) | 1371 (90.55) | 0.759 | 1.05 (0.78-1.42) | 0.758 | 1.06 (0.79-1.44) | 0.696 |
| rs3024270 C>G (HWE=0.162) | |||||||
| CC | 184 (26.29) | 415 (27.41) | 1.00 | 1.00 | |||
| CG | 362 (51.71) | 781 (51.59) | 1.05 (0.84-1.29) | 0.684 | 1.05 (0.85-1.30) | 0.679 | |
| GG | 154 (22.00) | 318 (21.00) | 1.09 (0.84-1.42) | 0.505 | 1.09 (0.84-1.42) | 0.505 | |
| Additive | 0.799 | 1.05 (0.92-1.19) | 0.503 | 1.05 (0.92-1.19) | 0.503 | ||
| Dominant | 516 (73.71) | 1099 (72.59) | 0.580 | 1.06 (0.87-1.30) | 0.580 | 1.06 (0.87-1.30) | 0.576 |
| Recessive | 546 (78.00) | 1196 (79.00) | 0.595 | 1.06 (0.85-1.32) | 0.595 | 1.06 (0.85-1.32) | 0.598 |
| rs217727 G>A (HWE=0.744) | |||||||
| GG | 331 (47.29) | 679 (44.85) | 1.00 | 1.00 | |||
| AG | 289 (41.29) | 674 (44.52) | 0.88 (0.73-1.06) | 0.187 | 0.88 (0.72-1.06) | 0.172 | |
| AA | 80 (11.43) | 161 (10.63) | 1.02 (0.76-1.37) | 0.900 | 1.02 (0.75-1.37) | 0.922 | |
| Additive | 0.359 | 0.96 (0.84-1.10) | 0.591 | 0.96 (0.84-1.10) | 0.561 | ||
| Dominant | 369 (52.71) | 835 (55.15) | 0.284 | 0.91 (0.76-1.09) | 0.284 | 0.90 (0.75-1.08) | 0.263 |
| Recessive | 620 (88.57) | 1353 (89.37) | 0.577 | 1.08 (0.82-1.44) | 0.577 | 1.08 (0.81-1.44) | 0.586 |
| Combined effect of risk genotypes c | |||||||
| 0 | 112 (16.00) | 258 (17.04) | 1.00 | 1.00 | |||
| 1 | 511 (73.00) | 1109 (73.25) | 1.06 (0.83-1.36) | 0.634 | 1.06 (0.83-1.36) | 0.643 | |
| 2 | 77 (11.00) | 147 (9.71) | 1.21 (0.85-1.72) | 0.298 | 1.22 (0.86-1.74) | 0.272 | |
| 1-2 | 588 (84.00) | 1256 (82.96) | 0.542 | 1.08 (0.85-1.37) | 0.542 | 1.08 (0.85-1.38) | 0.542 |
OR, odds ratio; CI, confidence interval; HWE, Hardy-Weinberg equilibrium. a χ2 test for genotype distributions between neuroblastoma patients and cancer-free controls. b Adjusted for age and gender. c Risk genotypes were carriers with rs2839698 AA, rs3024270 CG/GG and rs217727 AA genotypes.