Figure 2.

GV1001 inhibits invasion and migration capacity of CRPC cells. (A) Representative microscopic images of cells that had migrated into the lower chamber are shown at 200x magnification. The migrated cells were quantified using a bar graph. Data are expressed as mean ± standard deviation. *P<0.05 compared with controls. (B) At 0, 24, and 48 h after scratching in wound healing assays, cell migration was assessed by microscopy (100x magnification). (C) Western blot analysis for MMP-2, MMP-9, TIMP-1 and TIMP-2 in CRPC cells after GV1001 treatment. The β-actin housekeeping protein was used as an internal control.