Table 2.
The GO analysis of differentially expressed genes in the ccRCC
| Gene expression | Category | Term | Count | % | PValue | FDR |
|---|---|---|---|---|---|---|
| Upregulated | GOTERM_CC_DIRECT | GO:0031012~extracellular matrix | 31 | 8.93 | 2.21E-14 | 3.04E-11 |
| GOTERM_CC_DIRECT | GO:0005615~extracellular space | 61 | 17.57 | 6.12E-11 | 8.41E-08 | |
| GOTERM_CC_DIRECT | GO:0005581~collagen trimer | 15 | 4.32 | 1.09E-09 | 1.50E-06 | |
| GOTERM_CC_DIRECT | GO:0005576~extracellular region | 65 | 18.73 | 1.39E-09 | 1.92E-06 | |
| GOTERM_CC_DIRECT | GO:0009986~cell surface | 33 | 9.51 | 4.67E-09 | 6.42E-06 | |
| GOTERM_BP_DIRECT | GO:0030198~extracellular matrix organization | 26 | 7.49 | 5.52E-14 | 9.56E-11 | |
| GOTERM_BP_DIRECT | GO:0001666~response to hypoxia | 22 | 6.34 | 1.42E-11 | 2.46E-08 | |
| GOTERM_BP_DIRECT | GO:0007155~cell adhesion | 34 | 9.79 | 5.95E-11 | 1.03E-07 | |
| GOTERM_BP_DIRECT | GO:0002576~platelet degranulation | 14 | 4.03 | 7.88E-08 | 1.36E-04 | |
| GOTERM_BP_DIRECT | GO:0030199~collagen fibril organization | 9 | 2.59 | 5.86E-07 | 0.001014072 | |
| GOTERM_MF_DIRECT | GO:0005178~integrin binding | 14 | 4.03 | 7.23E-08 | 1.07E-04 | |
| GOTERM_MF_DIRECT | GO:0005201~extracellular matrix structural constituent | 10 | 2.88 | 3.84E-06 | 0.005662561 | |
| GOTERM_MF_DIRECT | GO:0005515~protein binding | 203 | 58.50 | 4.39E-06 | 0.006464779 | |
| GOTERM_MF_DIRECT | GO:0042605~peptide antigen binding | 7 | 2.01 | 1.03E-05 | 0.015247132 | |
| GOTERM_MF_DIRECT | GO:0042803~protein homodimerization activity | 32 | 9.22 | 1.59E-05 | 0.023366428 | |
| Downregulated | GOTERM_CC_DIRECT | GO:0070062~extracellular exosome | 41 | 23.83 | 6.28E-04 | 0.793504017 |
| GOTERM_CC_DIRECT | GO:0005615~extracellular space | 22 | 12.79 | 0.005456219 | 6.698549756 | |
| GOTERM_CC_DIRECT | GO:0031093~platelet alpha granule lumen | 4 | 2.32 | 0.011661381 | 13.81292879 | |
| GOTERM_CC_DIRECT | GO:0005576~extracellular region | 22 | 12.79 | 0.034131924 | 35.60273157 | |
| GOTERM_CC_DIRECT | GO:0016324~apical plasma membrane | 7 | 4.06 | 0.039386897 | 39.90451163 | |
| GOTERM_BP_DIRECT | GO:0042493~response to drug | 15 | 8.72 | 8.17E-07 | 0.001307793 | |
| GOTERM_BP_DIRECT | GO:0034765~regulation of ion transmembrane transport | 6 | 3.48 | 0.003572931 | 5.565651774 | |
| GOTERM_BP_DIRECT | GO:0008285~negative regulation of cell proliferation | 11 | 6.39 | 0.003600942 | 5.608115289 | |
| GOTERM_BP_DIRECT | GO:0007568~aging | 7 | 4.06 | 0.004178027 | 6.478970288 | |
| GOTERM_BP_DIRECT | GO:0007588~excretion | 4 | 2.32 | 0.004677244 | 7.226235366 | |
| GOTERM_MF_DIRECT | GO:0042802~identical protein binding | 18 | 10.46 | 5.70E-04 | 0.774996196 | |
| GOTERM_MF_DIRECT | GO:0005215~transporter activity | 7 | 4.06 | 0.011237989 | 14.28183863 | |
| GOTERM_MF_DIRECT | GO:0042813~Wnt-activated receptor activity | 3 | 1.74 | 0.017364869 | 21.24766214 | |
| GOTERM_MF_DIRECT | GO:0046934~phosphatidylinositol-4,5-bisphosphate 3-kinase activity | 4 | 2.32 | 0.019675974 | 23.73609635 | |
| GOTERM_MF_DIRECT | GO:0017147~Wnt-protein binding | 3 | 1.74 | 0.033119697 | 36.82480288 |